Poll results show a clear problem for Republicans in Ohio.
Ohio is a fickle state, but at the present, the Dems have a statewide dominance. It will only take a drop in Obama's poll number to drag down Ohio Dems, but that is all that will make it possible (outside of individual candidates screwing up). The Ohio GOP can try a culture war, but I think they will loose. Portman and DeWine are not culture warriors and wouldn't be able to stomach it. At this very early point, I don't see a way to win that doesn't involve the totally collapse of the support for the President.